Dancing With the Stars Finals: Which All-Star Should Win?

Source: http://www.thehollywoodgossip.com/2012/11/dancing-with-the-stars-finals-which-all-star-should-win/

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Inexpensive Web Hosting Services Could Make Difference To Your ...

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Source: http://www.hugohosting.com/inexpensive-web-hosting-services-could-make-difference-to-your-internetsite.html

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Retirement Rocks: Ho Ho Home

I last spent Christmas at home in England in 1999. ?Every Christmas since then I've been in America and the last 5 have seen me in Florida.

Now I'm not sure if it's common knowledge, but it tends to be a bit warmer at Christmas time in mid Florida than in West Yorkshire but after only 5 years of experiencing a warm Christmas, it's not like the weather here is a shock to me.

Last year I remember sitting by the swimming pool in sunny Buttonwood Bay and thinking that it was very pleasant but I kinda yearned for a classic white Christmas again. ?What the hell was I thinking about !?!

Leaving aside the weather for once, in many ways I could still be in America. ?I still watch all my favourite US tv shows, in some cases a day before they are shown over there. ?I still talk with US friends (just via the internet now) and I still shop using Amazon (just the UK version now). ?Speaking of shopping, we seem to have taken Black Friday to our retail hearts and, as our economy desperately needs an injection of consumer cash, we've turned it into a week long event. ?Yes Black Friday Week is the new hashtag to look for on Twitter and with online shopping far outstripping actually going to the shops, who cares if it's cold and wet and generally miserable outside. Let your fingers do the walking.

Yes Amazon is the new Santa's Grotto and their sleighs pull up right outside your front door to deliver the goodies, sometimes all wrapped and ready to be handed over or placed under the tree. Of course buying more online means credit card shopping so we're on a slippery slope there again. If you thought your flexible friend made shopping easy in the days of QVC, then try Amazon's one click option. ?They already have your credit card and delivery/billing address details so once you've decided on a gift, you just take the one click option and voila, the deal is done. Sit back and await delivery or even have it delivered to the recipient !

Simples.

How easy is THAT to get you deeper into debt when the time to pay comes round ! ?Remember when we all HAD to go out into the freezing cold and tramp up and down the streets, getting weighed down with presents like Crackerjack contestants. ?

CRACKERJACK !?

Are things better now that we can find the best deals online and with a few clicks, get all our presents bought and delivered without going out of our warm houses ? ?Were we more careful with our money and more thoughtful with our choice of presents when actually handing cash over a counter ?

The famous UK money expert Martin Lewis blogged the other day that in recent opinion polls, a majority of people felt the stress and expense of buying presents for adult family and close friends had been ruining their enjoyment of Christmas for decades. He proposed that people should?only buy presents for kids and that adults should forego this ritual. ?He expected to get 'bah humbug' comments but far from it, his ideas were supported by the majority and not only for financial reasons. ?

If you receive a present or even suspect you might get one, the pressure is on to reciprocate. ?Then you can get grumpy if you clearly spent more on YOUR present than the one you received. ?You also might get what you regard as a crap present. Worst of all, you also end up spending money you can't afford and pay for it all year.

How often do we hear people say "oh I'll be glad when it's all over." ?Now think how wonderful it would be if they only had to get a few presents for the kids they have or are close to and then plan on spending quality time and meet up with their family and adult friends over Christmas. ?Ok so I realise that more money might then be spent on food and booze this way but hey, less stress at least !

Maybe this will happen, maybe not. ?Initially the stores wouldn't like it but maybe, as a stopgap, adults could buy the occasional present for their friends during the year ! ?Spread the happiness around all year long and all that. ?Small thoughtful presents, maybe some home made ones, that show you care. Don't just store it all up for birthdays and Christmas.

And whether in sunny, warm Florida or cold, wet West Yorkshire, such time given by family and friends is much more precious than any present from Amazon.

When it comes to a choice between a few clicks at Christmas or hugs all year round, I know which mean more to me.

Source: http://retirement-rocks.blogspot.com/2012/11/ho-ho-home.html

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International Day for the Elimination of Violence against Women ...

Today is ending violence against women day. Engaging men and boys is an important strategy to achieve that, but it is important to state that engaging men and boys should not be considered as an end in itself, but should be regarded as a means or strategy to an end; it does not mean that engaging men and boys disregards the involvement of women and girls. It is important to engage with either or both sexes depending on the situation. At some point initiatives should work with both sexes together as gender is a relational concept.

The following information is shared from Partners for Prevention?s perspective. Partners for Prevention(P4P), a UNDP, UNFPA, UN Women & UNV Asia-Pacific Regional Joint Programme for Gender-based Violence Prevention, believes violence is preventable.

• What are the opportunities and challenges for engaging men and boys in promoting gender equality? How can men and boys be persuaded that gender equality also benefits them?

Opportunities for engaging men and boys in promoting gender equality are many. Anywhere they can make a difference and be change makers (especially in decision making positions, but certainly not limited to them): at home, in the workplace, at social events and sports activities, in the community, in society, etcetera. Generally, prevention approaches that engage men and boys entail strategies at the institutional/societal, community, family/interpersonal and individual level. Some examples are:

• Sensitizing men and boys to downsides of dominant masculinity and femininity norms and harmful practices to both men and women?s self-concepts and gender relations;
• Engaging men and boys in active transformation of their behaviors and practices, and hierarchical societal structures and processes;
• Encouraging equitable partnerships by changing power dynamics between men and women and building healthy relationships, and facilitating processes of shared decision making contributing to social stability and more sustainable livelihoods;
• Advocating for law and policy reforms, ensuring that legislative and policy frameworks acknowledge women needs and protection of basic (human) rights;
• Supporting institutional transformations;
• Involving male leaders (religious, cultural and political) and media to influence and transform men?s perspectives on gender equality aiming to change priorities and viewpoints of male decision makers at all levels.

Understanding of the influences of informal institutions, attitudes, norms, values, believes, power relations, family/gender roles and masculinities is important and, therefore, awareness should be raised and capacities should be developed to enable men and boys to act and transform these influences in the right direction. Besides for policy advocacy and programme development purposes, evidence from research can be used to raise awareness among and to strategically work with men and boys about how they can change certain inequitable and violent practices and behaviours.

It is also important to learn through systematic monitoring and evaluation of policies and programmes whether certain strategies were successful or not, and whether they can be adapted and/or scaled-up in other contexts. However, there remains limited evidence of what works well or what bring positive results.

A WHO report in 2007assessed 58 intervention programmes with men and boys in changing gender-based inequities, including 15 studies on GBV. Out of these 15 studies, four were considered ?effective? in terms of behavior or attitude change, seven were listed as ?promising? and the remaining four were reported ?unclear?. Programmes that were considered ?transformative? showed a higher effectiveness than programmes that were considered ?gender-neutral? or ?gender-sensitive?. Programmes that worked on multiple levels (from individual to societal) were considered to be more effective too. The types of intervention of the four ?effective? programmes were community outreach/mobilization and group education. Another WHO report in 2010described elements of successful programmes:

• Positive messaging
• Recognition of consequences of hegemonic masculinity
• Informed by proof through evaluation and research
• Acknowledgement that men are not homogenous
• Different levels of intervention
• Social change strategies like community outreach & mobilization and group education

Other evaluations of programmes (mainly on GBV in health and HIV/AIDS contexts) also indicated that primary prevention approaches can be effective especially through community outreach/mobilization and group education.

P4P identified 5 steps for effective primary prevention programming:

1. Apply research findings to identify priority changes needed to prevent future violence based on risk and protective factors and identify priority target groups;
2. Review global programme evidence and select appropriate intervention;
3. Apply theory of change to articulate the drivers of the problem, the anticipated change, the strategy to achieve change and to sustain it;
4. Contextualize and localize the intervention and consider how it will complement other activities that are already taking place;
5. Monitor and evaluate the intervention to enable adjustments based on findings and to add to the evidence base for future programming.

P4P also identified a framework for action to prevent GBVcontaining 7 key action areas that could be coordinated among different actors at different levels. These 7 PREVENT areas are based on existing global evidence on risk and protective factors and on effective interventions.

• Produce and apply evidence
• Respond to, support and protect those who experience violence
• Empower women and girls
• Value community engagement
• Educate youth and adolescents
• Nurture healthy family relationships
• Target alcohol and drug abuse

This provides an overall framework only. However, strategic priority areas for addressing violence should be adapted based on specific context of each setting.

Challenges:

There are probably as many opportunities as there are challenges. Gender inequality stems from informal and patriarchal institutions, attitudes, norms, values, believes, power relations, family/gender roles and masculinities that want to maintain the status of men which will have to be addressed in promoting gender equality.

Changing norms takes time and needs multi-pronged interventions and thus needs to engage various stakeholders and partners. Often, development programmes have short-life cycles and often are not strongly grounded on evidence and theories of change. It is important to have a long term investment in changing norms with right strategies, frequencies, consistencies, strong evidence- and theory-based grounding.

• In your area/region, what are examples of successful programmes in engaging men and boys in transforming discriminatory social norms? (E.g. socio-cultural practices, caring responsibilities, employment rights, gender- based violence...)

As mentioned before, not many formal evaluations have taken place or have been reported publicly. The success of many interventions is often based on subjective viewpoints or initial responses to activities that make an intervention promising. Besides that, transforming norms and behavior are long-term processes and are often not achieved through singular programmes.

However, examples of promising approaches initiated by partners of P4P are in the area of:

• Utilizing social media in combination of on ground activities to raise awareness and develop capacities on GBV prevention and provide space and opportunity for young people to be involved in preventing GBV;
• Utilizing mass media in combination with theater for development and capacity development activities focused on men and boys through civil society organizations, government and sports federations;
• School-based programmes with students from group 6-7 and their local context (teachers, parents, local government) to raise awareness, develop capacities and create a conducive environment on GBV prevention;
• Producing film with discussion guide and other training tools for raising awareness and develop capacities among young men and boys regarding the consequences of gender socialization and providing options for more equitable and non-violence practices;
• Raising awareness and developing capacities of groups of men to transform masculinities and achieve gender equality in their communities;
• Working with male leaders (religious, cultural and political) to change their perspectives which influence community norms and behaviors;
• Mobilizing communities through community communications and engagements.
• Male counseling with (potential) perpetrators, and working with couples on healthy relationship and parenting.

P4P facilitates regional cooperation and collaboration through its support of two sub-regional consortiums of practitioners to undertake coordinated capacity development initiatives in South Asia (SANAM: South Asian Network to Address Masculinities) and East & Southeast Asia (RLC: Regional Learning Community). Each consortium is promoting critical knowledge on masculinities, power, gender-justice, and violence prevention through collective learning, curriculum development, partnership and mentorship, and solidarity building that is adapted to their own settings. From these sub-regional consortiums, national groups have been formed to start a collective learning process that help local activists and practitioners to enhance knowledge and skills on transforming harmful masculinities to promote gender justice and prevent violence. P4P also provides capacity development events for and technical assistance to civil society organizations, government agencies, and partners on collecting and understanding evidence, and designing evidence- and theory-based prevention programmes.

P4P also contributes to the global knowledge base by conducting research on perpetration of violence against women (prevalence) and its risk and protective factors, including through interviews with men, which provides useful information as the basis for interventions (like determining priority changes for GBV prevention and selecting priority target groups).

More useful resources can be found via: http://www.partners4prevention.org/resources

• What actions should governments, donors, UN bodies and civil society take to support the engagement of men and boys in achieving gender equality?

Actions as suggested above should be undertaken by the various stakeholders. In order for actions to be successful coordination is important to ensure each stakeholder uses its comparative advantages and in such a way that the actions will be complementary. The 5 steps for effective primary prevention programmingand the PREVENT framework for action to prevent GBVwill be very useful tools to apply. ?

Contact: raymond.brandes@one.un.org

Source: http://www.engagingmen.net/blog/raymondbrandes/2012/11/international-day-elimination-violence-against-women

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New inquiry begins into case of woman who died after she was ...

Hundreds of women in Ireland are protesting, calling for legislative change after the death of Savita Halappanavar, who died after her requests for an abortion were rejected by her Irish doctors. NBC's Jim Maceda reports.

By Lorraine Turner and Conor Humphries, Reuters

DUBLIN, Ireland - Ireland has opened a new investigation into the death of a woman denied an abortion of her dying foetus, as the government scrambled to stem criticism of its handling of an incident that polarised the overwhelmingly Catholic country.

Savita Halappanavar, a 31-year-old dentist, was admitted to hospital in severe pain on Oct. 21 and asked for a termination after doctors said her baby would not survive, according to her husband, but in a country with some of the world's most restrictive abortion laws, surgeons would not remove the foetus until its heartbeat stopped days later.

He husband, Praveen Halappanavar believes the delay contributed to the blood poisoning that killed his wife on Oct. 28. He has said he would not cooperate with an investigation already launched by the country's health service because he did not believe it would be neutral.

---

On Friday, the Health Information and Quality Authority (HIQA) watchdog, which is government-funded but independent of the state health service, said it had also launched an investigation after receiving information from the health service and University Hospital Galway, where Halappanavar died.

A solicitor acting on behalf of the husband said the new inquiry was unlikely to be enough to satisfy his client.

"My client has always made his position very clear ... He wants a public inquiry. He has made it clear he wants to get to the truth of the matter, so I don't think that the framework of HIQA will suffice," Gerard O'Donnell, told RTE radio.

AFP - Getty Images

Savita Halappanavar is shown in a photo received from the Irish Times.

He added that the next step would be to consider an application to the European Court of Human Rights, which criticized Ireland's abortion ban in 2010.

Halappanavar's death has reopened a decades-long debate over whether the government should legislate to explicitly allow abortion when the life of the mother is at risk.

Irish law does not specify exactly when the threat to the life of the mother is high enough to justify a termination, leaving doctors to decide. Critics say this means doctors' personal beliefs can play a role.

Though the influence of the Catholic Church over Irish politics has waned since the 1980s, successive governments have been loath to legislate on an issue they fear could alienate conservative voters.

Ireland's abortion stance is enshrined in a 1983 constitutional amendment that intended to ban abortion in all circumstances. In 1992, when challenged in the "X-case" involving a 14-year-old rape victim, the Supreme Court ruled that abortion was permitted when the woman's life was at risk, including from suicide.

But successive governments refused to make clear the circumstances under which a threat would make an abortion legal. After several challenges, the European Court of Human Rights ruled in 2010 that Ireland must clarify its position.

Prime Minister Enda Kenny, whose ruling Fine Gael party made an election pledge not to introduce new laws allowing abortion, said last week he would not be rushed into a decision on the issue.

The government was forced into an embarrassing u-turn this week when it removed three Galway-based consultants from the health service inquiry following criticism from Praveen Halappanavar.

The issue has raised tensions between Fine Gael and the more socially liberal Labour Party, its junior coalition partner, which has campaigned for a clarification of the country's abortion rules.

The country's president, Michael D. Higgins, a former member of the Labour Party, weighed into the debate this week when he said an investigation was needed that satisfied the dead woman's family.

Opposition party Sinn Fein introduced a motion to parliament on Wednesday calling for parliament to legislate on abortion, but it was rejected.

"Successive governments over the past 20 years have failed in respect of legislation. That failure is in large measure due to fear or cowardice," said Mary Lou McDonald, vice president of Sinn Fein.?

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Copyright 2012 Thomson Reuters. Click for restrictions.

Source: http://worldnews.nbcnews.com/_news/2012/11/23/15390810-new-inquiry-begins-into-case-of-woman-who-died-after-she-was-refused-abortion-in-ireland

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New drug overcomes resistance in patients with rare sarcoma

Thursday, November 22, 2012

A new targeted drug demonstrated its ability to control metastatic gastrointestinal stromal tumor, an uncommon and life-threatening form of sarcoma, after the disease had become resistant to all existing therapies, report investigators at Dana-Farber Cancer Institute who led the worldwide clinical trial.

The treatment of gastrointestinal stromal tumor, or GIST, even in its advanced metastatic stage, has been dramatically improved with two oral targeted drugs ? imatinib (Gleevec) and sunitinib (Sutent). To date, these have represented the only two FDA-approved treatments with the proven ability to control GIST. However, in more than 85 percent of patients, GIST becomes resistant to these drugs after seven years and the disease worsens with fatal results.

The new study, whose results are being published in the Lancet, demonstrated that the oral drug regorafenib, which inhibits several cancer-promoting kinase enzymes, was able to control GIST for nearly four months longer than placebo in patients for whom Gleevec and Sutent were no longer effective, a result that was highly significant statistically.

"When added to best supportive care, regorafenib significantly improves disease control, as measured by progression-free survival time in patients with GIST after progression which represents failure of all other therapies," said George Demetri, MD, of Dana-Farber, principal investigator of this clinical trial.

Demonstrating the aggressive nature of this resistant disease, the study found that tumors objectively grew in less than a month, on average, in GIST patients who were initially randomized to receive a placebo. The study's "cross-over" design made it possible to treat those patients whose tumors grew, and 85 percent of the patients initially on placebo were able to receive regorafenib, which then controlled the disease in these patients as well.

Because of the study's cross-over design, Demetri said, it was not expected to prove that the patients initially randomized to receive regorafenib survived longer ? the researchers would have had to withhold the drug from the placebo patients to demonstrate that difference. "But there is no question that people are living longer" with regorafenib treatment, he said, based on the results of this trial.

An application to have regorafenib approved for use in resistant GIST is under an accelerated review by the Food and Drug Administration, Demetri said.

GIST is a rare form of sarcoma that develops in the gastrointestinal tract, mainly in the stomach and small intestine. GIST is estimated to affect more than 5,000 people per year in the United States and about 8,000 in Europe.

Regorafenib is a novel rationally designed drug manufactured by Bayer HealthCare Pharmaceuticals that was FDA-approved in September 2012 to treat metastatic colon cancer after failure of standard chemotherapy. It blocks several cancer-promoting enzymes called kinases, which spur runaway growth in GIST and other cancers.

The phase 3 international trial involved 199 treatment-resistant GIST patients at 57 hospitals in 176 countries. Of the 199 patients, 133 received a regorafenib pill daily for three weeks followed by a one-week break, while 66 received a matching placebo. The patients were monitored for at least one year after the trial began.

As for other targeted therapies, the drug did not often shrink tumors but controlled the disease for an average of 4.8 months before it progressed, while patients in the placebo group experienced less than one month (0.9 month) before the disease worsened. There was a high rate of adverse effects including high blood pressure, fatigue, diarrhea, and redness, swelling, numbness and peeling of skin on the hands and feet. These side effects were managed by reducing or interrupting the regorafenib treatment, the report said.

A companion report in The Lancet said that the drug had a "modest" benefit in patients with metastatic colon cancer. A commentary by David Cunningham, MD, of the Royal Marsden Hospital in England, said, "In the relatively rare GIST, the case for routine use of this drug in patients following failure of existing treatments is strong."

Demetri added "We know that regorafenib can inhibit many of the mutated proteins and abnormal signals that cause this cancer, and the next step will be to investigate the molecular mechanisms by which this new treatment can control GIST after resistance appears to other 'targeted therapy' drugs for this aggressive malignancy."

The clinical trial was supported, in part, by Bayer HealthCare Pharmaceuticals, as well as the Ludwig Center at Dana-Farber/Harvard Cancer Center.

###

Dana-Farber Cancer Institute: http://www.dfci.harvard.edu

Thanks to Dana-Farber Cancer Institute for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 70 time(s).

Source: http://www.labspaces.net/125439/New_drug_overcomes_resistance_in_patients_with_rare_sarcoma

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How to set alarms and timers using Siri

Complete guide to Siri commands for alarms, timers, and the clock

Siri ties right into the iOS Clock app on your iPhone 5, iPhone 4S, iPad 4, iPad mini, and iPod touch 5, which means if you want to be woken up at 7am, have a timer set for 10 minutes so the cookies don't burn, or find out what the hour is in Australia before you call, Siri can keep you alerted and on time.

• How to set an alarm with Siri
• How to set a repeating alarm with Siri
• How to show current alarms with Siri
• How to change alarms with Siri
• How to turn off alarms with Siri
• How to delete alarms with Siri
• How to set a timer with Siri
• How to show, stop, or re-start a timer with Siri
• How to change a timer with Siri
• How to find out the time with Siri

How to set an alarm with Siri

Siri can set alarms quickly and easily.

1. Press and hold down the Home button to activate Siri.
2. Tell Siri to set an alarm, along with the time. For example: "Set an alarm for 8pm", "Set an alarm for 5 minutes from now", "wake me up at 9am".

Siri will display the alarm widget on the screen. If you change your mind about the alarm, you can simply toggle it to "off". You can also tap the widget to be taken to the Clock app.

Note: Siri can?t set an alarm for more than one day in advance. If you try to use Siri to set an alarm further in advance, you'll be asked if you want to set a Reminder instead.

How to set a repeating alarm with Siri

If you want an alarm to repeat, for example, to wake you up at the same time every day, Siri can set that up for you as well.

1. Press and hold down the Home button to activate Siri.
2. Tell Siri to set an alarm, along with the time. For example: "Set an alarm for 6pm every weekday" or "wake me up at 9am ever day".

When Siri displays the alarm widget, the repetition interval is show about the on/off toggle switch.

How to show current alarms with Siri

Over time, you may lose track of all the alarms you've set, especially inactive ones. Siri can show you list of all alarms, and their current status -- on or off.

1. Press and hold down the Home button to activate Siri.
2. Tell Siri to: "Show all alarms".

You can quickly toggle any of the alarms shown from on to off or vice versa, or ask Siri to change or delete them. (See below.)

How to change an alarm with Siri

If you set an alarm, but later need to change it, Siri can handle that for you as well.

1. Press and hold down the Home button to activate Siri.
2. Tell Siri which alarm you want to change, and what time you want to change it to. For example: "Change my 9am alarm to 9:30am."

How to turn off alarms with Siri

Nights get late, meetings get canceled, and plans change. If you no longer need an alarm, you can ask Siri to turn it off.

1. Press and hold down the Home button to activate Siri.
2. Tell Siri which alarm you want to turn off. For example: "Turn off my 8am alarm" or even "turn off all alarms."

Note: Turning off is different than canceling or deleting. When you turn an alarm off, it remains available for you to quickly turn back on at any time, even manually. When you cancel or delete an alarm, it's gone completely and needs to be recreated if you ever want to use it again.

How to cancel alarms with Siri

When turning off alarms isn't enough, and you want them completely gone from your Clock system entirely, Siri a fast way to delete a specific alarm, and an incredibly fast way to delete all of them.

1. Press and hold down the Home button to activate Siri.
2. Tell Siri which alarm you want to cancel. For example: "Cancel my 9:30am alarm" or go for the nuclear option and "cancel all alarms".

How to set a timer with Siri

Since the Clock app can set timers as well as alarms, Siri can set timers as well as alarms. Whether you're waiting for your cookies to bake, or your next set of circuit training to begin, Siri can make sure you always alerted at exactly the right time.

1. Press and hold down the Home button to activate Siri.
2. Tell Siri to set the timer, and for how long. For example: "Set a timer for 10 minutes".

The Timer widget will remain visible on your screen until the timer goes off, or you leave Siri. Tap the timer widget to launch the Clock app and access the manual controls.

Note: Siri can only run one timer at a time. If you try to set another, Siri will ask you if you want to keep the current one or change to the new one. (See below.)

How to show, stop, or re-start a timer with Siri

If Siri is no longer displaying your timer, you can easily ask it to show you the timer again, and to pause/stop or start it whenever you like.

1. Press and hold down the Home button to activate Siri.
2. Tell Siri what you want to do with the current time. For example: "Show timer", "stop timer", "start timer".

How to change a timer with Siri

Siri can also change the duration of a timer, if you need to increase or decrease the length for any reason.

1. Press and hold down the Home button to activate Siri.
2. Tell Siri to change the timer. For example: "Change timer to 5 minutes".

How to find out the time with Siri

What if you need to know the time in Cupertino, California so you don't miss that Apple keynote? Or you want to find out the time in Rome, Italy, so you don't wake up nono too early? Just ask Siri.

1. Press and hold down the Home button to activate Siri.
2. Ask Siri the time in any location around the world. For example: "What's the time in Rome, Italy?"

Tap the clock widget to go to the Clock app for more options.

How to get more help with Siri

If you still need help with setting up or using Siri with your iPhone Contacts, or any other Siri feature, head on over to our Siri Forum and ask away!

Note: This article is an updated version of a previous how-to, adding video as well as new features from iOS 6, and newly supported devices.

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/PrrIPXkWMj4/story01.htm

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